Abstract
PuraStat® is a fully-synthetic solution comprised of RADA-16, a poly-peptide chain comprised of four naturally occurring amino acids in a repeated sequence, which has a molecular structure capable of self assembling scaffold formation. Contact between the acidic peptide solution and a base such as blood causes the rapid formation of fibres in the aqueous solution which yields a peptide hydrogel. In surgery, this hydrogel allows for rapid haemostasis through superficial coating of broken blood vessel, and coagulation within the deeper vascular wall. In addition, the 3D-nanofiber scaffold has a similar structure to the natural extra-cellular matrix, which results in adequate adherence of the cells and tissue. Its ease of application, being a clear solution available in a pre-filled syringe, and ability to achieve rapid haemostasis support are of particular value in nasal endoscopic surgery. Additionally, preliminary findings have demonstrated the use of PuraStat® is associated with satisfactory postoperative wound healing without the formation of tissue adhesions, whilst maintaining haemostasis.
Biography
Dr. Arjuna Ananda is an Ear, Nose and Throat surgeon working in Sydney, Australia and the current head of the Ear, Nose and Throat Surgery Department at Royal Prince Alfred Hospital. His area of expertise is rhinological surgery, having attained his fellowship in advanced sinus surgery and anterior skull base surgery, and is a regularly invited lecturer at industry events and at Western Sydney University. He runs a sleep and snoring clinic at Concord Hospital and has a specific interest in functional rhinoplasty and the use of coblation in the management of sleep apnoea. Dr. Michael Lee is a resident medical officer at Royal North Shore Hospital in Sydney, Australia. He got his B Medicine, B Surgery at Western Sydney University, and has an interest in Ear, Nose and Throat surgery and advancement of biotechnology in the application of surgery. Currently his research focuses on the use of a self-assembling peptide hydrogel in improving intra-operative and post-operative patient outcomes.